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Isrul, Muhammad
- Gastroprotective Effect of Lannea coromandelica Stem Bark in Rat induced by Aspirin
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Authors
Affiliations
1 Department of Pharmacy, STIKES Mandala Waluya, Kendari, ID
1 Department of Pharmacy, STIKES Mandala Waluya, Kendari, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1646-1648Abstract
Lannea coromandelica is one of plant dispersed in Sulawesi. Inhabitants from the Southeast Sulawesi apply Lannea coromandelica Bark to relief symptom of gastritis or peptic ulcer. Phenolic compounds of Lannea coromandelica Stem bark contains antioxidant activity. The study investigated the gastroprotective effect of Lannea coromandelica stem bark. Ethanol extract of Lannea coromandelica Stem bark (LCSB) was evaluated its anti-ulcer activity using aspirin-induced rats. Normal group was given 0.05% Na CMC. Positive group was given sucralfat 360 mg / kgBW and aspirin 600mg/kg BW, group I was given extract of LCSB at dose 400 mg / kgBW and aspirin 600 mg/kgBW, group II was given extract of LCSB at dose 800 mg / kg BW and aspirin 600 mg/kgBW, and group III was given extract of LCSB at dose 1200 mg / kg BW and aspirin 600 mg/kg BW. Extract of LCSB was administered orally in various doses for three days prior to the ulcer induction. On the 4th-day rats, all rats were observed 8 hours after aspirin induction to determine ulcer index and percent inhibition. Results of this study revealed that LCSB extract significantly reduced the ulcer index and percent inhibition (p=0.00). Extract of LCSB shows gastroprotective activities.Keywords
Bark of Javanesse wood, Lannea coromandelica, Aspirin, Gastroprotective, Rat.References
- Nie Y, Liana LK, Evacuasiany E. The Effect of Kencur's Rhizome Ethanol Extract (Kaempferia galangal L.) Against Gastric Mucosal to Swiss Webster Mice in Induce by Asetosal. Jurnal Medika Planta. 2012;2(1).
- Oviedo JA, Wolfe MM. Management of stress-related erosive syndrome. Current Therapy in Gastroenterology and Liver Disease, fifth edition. Hamilton, Ontario: BC Decker, Inc. 2005:161-6.
- Febrina T. Efek Seduhan Jahe Terhadap Tingkat Kerusakan Mukosa Gaster Mencit yang Diinduksi oleh Aspirin Ditinjau dari Gambaran Histopatologi, Skripsi, Fakultas Kedokteran Universitas Andalas: Padang. 2008.
- Prawirodiharjo E. Uji Aktivitas Antioksidan dan Uji Toksisitas Ekstrak Etanol 70% dan Ekstrak Air Kulit Batang Kayu Jawa (Lannea coromandelica), 2014, Bachelor Thesis, Program Studi Farmasi, UIN Syarif Hidayatullah: Jakarta.
- Wirastuty RY. Uji Efektifitas Gel Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea coromandelica) Pada Kelinci (Oryctolaguscuniculus) Sebagai Obatpenyembuhan Luka Bakar. Journal of Pharmaceutical Science and Herbal Technology. 2017;1(1):32-5.
- Wahid A. In Vitro Phytochemical and Biological Investigation of Plant Lannae coromandelica (Family: Anaradiceae). Thesis. 2009.. Department of Pharmacy, East West University: Bangladesh.
- Sari PS, Mun’im AB, Kusumaningtyas D. Aktivitas Gastroprotektif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta indica A. Juss) dan Rimpang Kunyit (Curcuma domestica Linn.) pada Tikus Putih yang Diinduksi Asetosal (Gastroprotective Activity of Combination of Neem. Jurnal Ilmu Kefarmasian. 2013;11(2):97-101.
- Venkata, S.S.N., Kantamredi, Nagendra L.Y., dan Satyanarayana, K.V.V.V. 2010. Preliminary Phytocemical Analysis of Some Important Indian Plant Species. International Journal of Pharma and Bio Sciences. 1 (4): 351-358.
- Rahman, M.S., Bilkis, B., Chowdhury, K.M., Rahman dan Rashid, M.A. 2008, Preliminary cytotoxicity screening of some of Bangladesh. J.Pharm. Science. 7: 47-52.
- Indraswary R. Efek Konsentrasi Ekstrak Buah Adas (Foeniculum vulgare Mill.) Topikal pada Epitelisasi Penyembuhan Luka Gingiva Labial Tikus Sprague Dawley In Vivo. Majalah Universitas Sultan Agung. 2011.
- Phytochemical Analysis, Standardization and Cytotoxic Activity of Curcuma aureginosa Extract in Human Breast Cancer (MCF-7) Cell Line
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Authors
Muhammad Isrul
1,
Risky Juliansyah
1,
Ahmad Saleh
1,
Wa Ode Yuliastri
1,
Jastria Pusmarani
1,
Himaniarwati
1,
Wa Ode Wahyuni Maulidina
1
Affiliations
1 Department of Pharmacy, STIKES Mandala Waluya Kendari, South-East Sulawesi, ID
1 Department of Pharmacy, STIKES Mandala Waluya Kendari, South-East Sulawesi, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1967-1973Abstract
Last several years, researches about the plant as an alternative treatment of breast cancer have been developed. Curcuma aureginosa has been applied empirically as a breast cancer treatment and provide a satisfying result. The aim of this study is to examine cytotoxic activity of C.aureginosa extract to MCF-7 breast cancer cells, phytochemical analysis, and standardization of extract. Examination of breast cancer activity conducted by MTT method, extract was examined at concentration of 2000, 1000, 500, 250, 125, 62.5, 32.25, 15.625, and 7.8125 μg/ml, doxorubicin 1 μg/ml is applied as a positive control. Phytochemical Analysis conducted by GC-MS, and standardization of extract conducted based on Indonesia Pharmacopeia. The results reveal that extract has cytotoxic activity toward MCF-7 breast cancer cell. Concentration of 2000, 1000, 500, 250μg/ml has similar activity with doxorubicin 1 μg/ml. IC50 value of the extract is 76.24 μg/ml with 48 hours incubation. Standardization result determines extract profile and completes the standard of Indonesia Pharmacopeia. Phytochemical analysis result reveals Germacra-1(10), 4-diene-12-oic acid 6 alpha hydroxy gamma lactone (25.12%) and Cycloisolongifolene, 8, 9-dehydro-9-formyl- (21.61%) as a major compound. Cycloisolongifolene, 8, 9-dehydro-9-formyl-, Alpha-Humulene, Curcumene, and Curzerene assumed as cytotoxic toward MCF-7 breast cancer cell.Keywords
Curcuma aureginosa, Breast Cancer, MCF-7, MTT, GC-MS, Standardization.References
- WHO. Cancer. Available from: URL :http://www.who.int/mediacentre/factsheets/fs297/en/
- Desai SA, Sukhramani PS, Suthar MP, Patel VP. Biological Cytotoxicity Evaluation of Sulfonamide Derivatives as Anti-Lung and Anti-Breast Cancer Activity. Asian Journal of Research in Chemistry. 2011 Apr 1; 4(4):671-7.
- Abdullah AS, Mohammed AS, Rasedee A, Mirghani ME. Oxidative stress-mediated apoptosis induced by ethanolic mango seed extract in cultured estrogen receptor positive breast cancer MCF-7 cells. International journal of molecular sciences. 16(2); 2015: 3528-3536.
- Barath M, Aravind J, Sivasamy R. Investigation of Antimicrobial activity and Chemical Constituents of Eragrostiscynosuroides by GC-MS. Research Journal of Pharmacy and Technology. 2016 Mar 1; 9(3):267.
- Kumar V, Sharma A, Kaur H, Thukral AK, Bhardwaj R. Phytochemical profiling of the leaves of Chenopodium and Polygonum using GC-MS. Research Journal of Pharmacy and Technology. 2015 Dec 1; 8(12):1629.
- Isrul M., Idrus M., Hasanuddin S, Mashar HM, MuthmainnahA. Antimycobacterial activity of Gynuraprocumbens leaves extract against Mycobacterium tuberculosis. International Journal of Green Pharmacy.12(03); 2018:163-167
- Aravind R, Bindu AR, Bindu K, Alexeyena V. GC-MS Analysis of the Bark Essential Oil of Cinnamomummalabatrum (Burman. F) Blume. Research Journal of Pharmacy and Technology. 2014 Jul 1; 7(7):754.
- Mukesh KS, Prathapan A, Kushagra NS, Ishwarya KG, Raghu. Cytotoxic and Antimicrobial Activity of Methanolic Extract of Boerhaaviadiffusa L. Research J. Pharm. and Tech.3 (4.2010; 1061-1063
- Nirmala MJ, Samundeeswari A, Sankar PD. Natural plant resources in anti-cancer therapy-A review. Research in Plant Biology. 15; 1(3); 2011
- Saha D, Paul S. Cytotoxic Activity of Methanolic Extract of Alpiniaconchigera Griff (Family: Zingiberaceae). Asian Journal of Pharmaceutical Research. 2012; 2(2):86-8.
- Kamazeri TS, Samah OA, Taher M, Susanti D, Qaralleh H. Antimicrobial activity and essential oils of Curcuma aeruginosa, Curcuma mangga, and Zingibercassumunar from Malaysia. Asian Pacific journal of tropical medicine.5(3); 2012: 202-209.
- Reanmongkol W, Subhadhirasakul S, Khaisombat N, Fuengnawakit P, Jantasila S, Khamjun A. Investigation the antinociceptive, antipyretic and anti-inflammatory activities of Curcuma aeruginosa Roxb. extracts in experimental animals. Songklanakarin J Sci Technol. 28(5); 2006: 999-1008.
- Suphrom N, Pumthong G, Khorana N, Waranuch N, Limpeanchob N, Ingkaninan K. Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb. Fitoterapia. 83(5); 2012:864-871.
- Ramasubramaniaraja R. Pharmacognostical phytochemical including GC-MS investigation of ethanolic leaf extracts of Abutilon indicum (Linn). Asian Journal of Pharmaceutical Analysis. 2011; 1(4):88-92.
- Sanjeev PA, Doshi GM. Chemical constituents from Polyalthialongifolia seeds extract by gas Chromatography-Mass spectroscopy (GC-MS) studies. Research Journal of Pharmacy and Technology. 2018 Jun 30; 11(6):2489-92.
- Suman T, Chakkaravarthi K, Elangomathavan R. Phyto-chemical profiling of Cleistanthuscollinus leaf extracts using GC-MS analysis. Research Journal of Pharmacy and Technology. 2013; 6(11):1173-7.
- Graidist P, Martla M, Sukpondma Y. Cytotoxic activity of Piper cubeba extract in breast cancer cell lines. Nutrients. 10; 7(4); 2015 :2707-2718.
- Vijayarathna S, Sasidharan S. Cytotoxicity of methanol extracts of Elaeisguineensis on MCF-7 and Vero cell lines. Asian Pacific Journal of Tropical Biomedicine. 2(10); 2012:826-829.
- Ministry of Health of the Republic of Indonesia. General Standard Parameters of Medicinal Plant Extracts. Ministry of Health of the Republic of Indonesia, Jakarta. 2000
- Saifudin A, Rahayu and Teruna. Standardization of Natural Medicine Materials..GrahaIlmu: Yogyakarta 2011
- Rehman K, Fatima F, Waheed I, Akash MS. Prevalence of exposure of heavy metals and their impact on health consequences. Journal of cellular biochemistry. 2018 Jan; 119(1):157-184.
- Rahman NH, Vigneswari S, Ahmad A, Mohamad H, Muhammad TS. Cytotoxic effects and evidence of apoptosis from avecenniaalba extracts on human breast cancer cell line (MCF-7). Journal of Sustainability Science and Management. 2017 Dec; 12(2):80-88.
- Houdkova M, Rondevaldova J, Doskocil I and Kokoska L. Evaluation of antibacterial potential and toxicity of plant volatile compounds using new broth microdilution volatilization method and modified MTT assay. Fitoterapia, :118; 2017 : 56–62.
- Xu M, McCanna DJ and Sivak JG. Use of the viability reagent Presto Blue in comparison with alamar Blue and MTT to assess the viability of human corneal epithelial cells. Journal of Pharmacological and Toxicological Methods, 71; 2015: 1–7.
- Devi DM, Banu N. Anti-Proliferative activity of Chlorophyllin from Phyllanthus Emblica L. against MCF-7 and Vero Cell line. Research Journal of Pharmacy and Technology. 2017 Feb 1; 10(2):516-24.
- Chen CC, Chen Y, Hsi YT, Chang CS, Huang LF, Ho CT, Way TD and Kao JY. Chemical constituents and anticancer activity of Curcuma zedoaria roscoe essential oil against non-small cell lung carcinoma cells in vitro and in vivo. Journal of agricultural and food chemistry. 61(47); 2013. 11418-11427.
- El Hadri A, del Río MÁG, Sanz J, Coloma AG, Idaomar M, Ozonas BR, González JB, Reus MIS. Cytotoxic activity of α-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells. An R AcadNac Farm. 76(3); 2010: 343-356.
- Shin Y and Lee Y. Cytotoxic activity from Curcuma zedoaria through mitochondrial activation on ovarian cancer cells. Toxicological research. 29(4); 2013: 257.
- Wang Y. Li J. Guo J. Wang Q. Zhu S. Gao S. Yang C. Wei M. Pan X. Zhu W and Ding D. Cytotoxic and antitumor effects of curzerene from Curcuma longa. Planta Medica. 83(01/02); 2017 :23-29
- Antidiabetic Effect of the Combination of Garlic Peel Extract (Allium sativum) and Onion Peel (Allium cepa) in Rats with Oral-Glucose Tolerance Method
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Authors
Nikeherpianti Lolok
1,
Harlyanti Muthmainnah Mashar
2,
Itma Annah
2,
Ahmad Saleh
1,
Wa Ode Yuliastri
1,
Muhammad Isrul
1
Affiliations
1 Departement of Pharmacy, STIKES Mandala Waluya Kendari, ID
2 Department of Nutrition, Health Polytechnic of Health Ministry of Palangka Raya, ID
1 Departement of Pharmacy, STIKES Mandala Waluya Kendari, ID
2 Department of Nutrition, Health Polytechnic of Health Ministry of Palangka Raya, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2153-2156Abstract
Diabetes mellitus threat in the middle of the society has become a scare disease because in each 10 seconds in the world people die because the complication of that disease. The application of natural drug has been applied empirically by the society, such as the application of the extract of garlic peel and onion peel each has been reported has hypoglycemic effect and potential as an antioxidant which can repair damage cell body, include pancreas. The aim of this study is to understand the effect of the combination of garlic peel extract and onion peel extract to the decreasing of blood glucose level in normal rats compare to the combination of metformin and glibenclamide and to the decreasing of blood glucose level in rats induces diabetic drug compare to pen insulin. This laboratory experimental study aims to understand the anti-diabetic effect of the combination of garlic (Allium sativum) peel extract and onion (Allium cepa) peel extract in rats induced glucose per orally and alloxan. Test of anti-diabetic effect, test animals are divided into 7 group, 3 groups to oral glucose tolerance test in normal rats (negative control, positive control, and extract combination) and 4 groups to test in rats induced diabetes (negative control, positive control, diabetic control, and combination extract). The result of oral glucose tolerance test to the normal groups reveal that the combination of this extract significantly decrease blood glucose level compare to the negative control group specifically in the 0, 30th, 60th, and 90th minutes (p<0.05). In the test to the diabetic induces rats reveal that the combination of this extract also significantly decrease the blood glucose level compare to diabetic group (p<0.05), meanwhile the result is not real difference to the positive control group (p>0.05). This study shows that the combination of peel garlic extract and onion peel extract have the ability to decrease the blood glucose level both in normal rats induced glucose and rats induced diabetic.Keywords
Garlic Peel, Allium sativum, Onion Peel, Allium cepa, Diabetes Mellitus, Oral Glucose Tolerance.References
- WHO. 2015. Diabetes. http ://www.who.int/mediacentre/factsheets/f5312/en.
- Rahayu S, Kurniasih N, Amalia V. Ekstraksi dan Identifikasi Senyawa Flavonoid dari Limbah Kulit Bawang Merah sebagai Antioksidan Alami. al Kimiya. 2015,15;2(1):1-8.
- Setiawan AS, Yulinah E, Adnyana IK, Permana H, Sudjana P. Efek antidiabetes kombinasi ekstrak bawang putih (Allium sativum Linn.) dan rimpang kunyit (Curcumma domestica Val.) dengan pembanding glibenklamid pada penderita Diabetes Melitus Tipe 2. Majalah Kedokteran Bandung. 2011;43(1):26-34.
- Sornalakshmi V, Tresina Soris P, Paulpriya K, Packia Lincy M, Mohan VR. Oral glucose tolerance test (OGTT) in normal control and glucose induced hyperglycemic rats with Hedyotis leschenaultiana DC. Group. 2016;1:0-9.
- Suresha RN, Sushma VN, Ashwini V, Kalabharathi HL, Jayanthi MK, Prathima C. The effect of nifedipine on oral glucose induced glycaemic changes in normal albino rats. pancreas. 2012;10(12):13.
- Ngatidjan,Metode Laboratorium Dalam Toksikologi. Penerbit Bagian Farmakologi dan Toksikologi Fakultas Kedokteran Universitas Gajah Mada.Yogyakarta.2006
- Anitha M, Sakthidevi G, Muthukumarasamy S, Mohan VR. Effect of Cynoglossum zeylanicum (Vehl ex Hornem) Thunb. ex Lehm on oral glucose tolerance in rats. Journal of Applied Pharmaceutical Science. 2012; 1;2(11):75.
- Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutrition journal. 2002 Dec;1(1):4.
- Kairupan BY, Wowor MP, Mambo C. Pengaruh Pemberian Ekstrak Umbi Bawang Merah (Allium Cepa L) Terhadap Kadar Gula Darah Tikus Wistar (Rattus Norvegicus) Yang Diinduksi Dengan Aloksan. Jurnal e-Biomedik. 2015;9;3(1).
- Antidepressant Activity and Identification of Chemical Compounds Extract Mustard Leaves (Brassica juncea L.)
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Authors
Affiliations
1 Departement of Pharmacy, STIKES Mandala Waluya Kendari, South-East Sulawesi, ID
1 Departement of Pharmacy, STIKES Mandala Waluya Kendari, South-East Sulawesi, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3223-3227Abstract
Depression is a common disease that affects more than 300 million people of all ages which is generally accompanied by insomnia. In 2030 this disease is thought to be the biggest contributor to the burden of the disease worldwide. Mustard is one of the vegetables produced in Southeast Sulawesi, especially in the Wua-wua area, Kendari, where its use as a medicine is still lacking. This study aims to test the antidepressant activity of mustard leaf extract, and identify the class of extract chemical compounds. The long-term goal of this research is the manufacture of herbal preparations for either herbal or standardized herbs for the treatment of depression. Mustard leaf extract obtained from maceration contains flavonoids, saponins, sterols/triterpenoids, and terpenes. The testing of activities with the Open field test method, Forced swim test, and Tail suspension test of mice were carried out at several test doses (100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg bw). The test results obtained was analyzed by One-way Analysis of Variance (ANOVA) (SPSS 16.0 program) indicating that the antidepressant effect shown in the extract dose of 100 mg/kg bw and 200 mg/kg bw.Keywords
Mustard Leaves, Depression, Insomnia, Chemical Compounds.References
- Kim SY, Ahn SH, Kim HH. Antidepressive effects of Gami-Shinkiwhanin Immobilization stressed aging Mice. Research Journal of Pharmacy and Technology. 2018 May 30;11(5):1906-16
- Vijayalakshmi K. Assessment of Depression among Cancer Patients. Asian Journal of Nursing Education and Research. 2018;30;8(1):11-14.
- WMHF. Depression: A Global Crisis. Supplementary Material. USA. 2012; 4.
- Basic Health Research (Riskesdas). Health Ministry Research and Development Agency of the Republic of Indonesia in 2013. (http://www.depkes.go.id/resources/download/general/Results%20Riskesdas% 202013.pdf., Accessed 04 April 2017).
- Venkatesh G, Kalaiyarasi C, Ramanathan M. Antidepressant like Effect of Gabapentin Decreases the Immobility Time in Despair Animal Models in Mice: Roll of Serotonergic System in it. Research Journal of Pharmacy and Technology. 2011;4(11):1702-1706.
- Sanmugam K. Depression is a risk factor for Alzheimer disease-review. Research Journal of Pharmacy and Technology. 2015 Aug 1;8(8):1056
- Sharma I, Kaur M, Parashar B, Kainth A. Depression: An Overview. Asian Journal of Research in Pharmaceutical Science. 2014;4(1):28-31
- Fekadu, N., Shibeshi, W., Engidawork, E. Major Depressive Disorder: Pathophysiology and Clinical Management. Journal of Depression and Anxiety. 2017; 6.
- Vishnupriya V, Gayathri R. Herbal Remedies for Anxiety and Depression-A Review. Research Journal of Pharmacy and Technology. 2016 Aug 1;9(8):1253
- Tripathi K. Herbs for Depression: A Review. Research J. Science and Tech. 1(2):. 2009: 55-62
- Thakur A.K., Chatterjee S.S., Kumar V. Antidepressant-like Effects of Brassica juncea L. Leaves in Diabetic Rodents. Indian Journal Experimental Biology. 2014; 52: 613-622.
- Parikh, H., Khanna, A. Pharmacognosy and Phytochemical Analysis of Brassica juncea Seeds. Phcog J. 2014; 6 (5): 47.
- Lakshmi AJ, Satyavthi D. Evaluation of Anti Depressant and MAO Inhibitory Activity of Rhodiolarhodantha rhizome methanolic extract. Research Journal of Pharmacy and Technology. 2015 Mar 1;8(3):310
- Tiwari, P., Kumar, B., Kaur, M., Kaur, G., Kaur, H. Phytochemical Screening and Extraction: A Review, International Pharmaceutical Science. 2011; 1: 1.98-106.
- Pamilutsih, P.M. Antidepressants Combination of Ethanol Extract of Clove Flowers (Syzygium aromaticum) and Acetone Extract of Banana Skin (Musa paradisiaca) Against Lokomotor Activity and Decrease Immobility Time in Mice. Muhammadiyah Surakarta university. 2017; 4.
- Lakshmi AJ, Satyavthi D. Evaluation of Anti Depressant and MAO Inhibitory Activity of Rhodiolarhodantha rhizome methanolic extract. Research Journal of Pharmacy and Technology. 2015 Mar 1;8(3):310
- Sinata, Novia. Effects of Curcumin on Drug Discontinuation Symptoms in the Alcohol Dependency Mice Model. Bandung Institute of Technology. 2015; 15.
- Kim SY, Ahn SH, Kim HH. Antidepressive effects of Gami-Shinkiwhanin Immobilization stressed aging Mice. Research Journal of Pharmacy and Technology. 2018 May 30;11(5):1906-1916.